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Environmental pollution and DNA methylation: carcinogenesis, clinical significance, and practical applications

Yi Cao

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 261-274 doi: 10.1007/s11684-015-0406-y

Abstract: In this review, the roles of DNA methylation in carcinogenesis and their significance in clinical medicine

Keywords： environmental pollution     DNA methylation     cancer     biomarker     diagnosis     therapy     prevention    

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Structural dimension optimization and mechanical response analysis of fabricated honeycomb plastic pavement slab

Zixuan CHEN; Tao LIU; Xiao MA; Hanyu TANG; Jianyou HUANG; Jianzhong PEI

Frontiers of Structural and Civil Engineering 2022, Volume 16, Issue 7,   Pages 896-908 doi: 10.1007/s11709-022-0856-7

Abstract: Significance of different influencing factors, including wheel load, elastic modulus of plastic material

Keywords： honeycomb structure     plastic pavement     dimension optimization     mechanical response     factor significance    

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Prognostic significance of clinicopathologic parameters in gastrointestinal stromal tumors: a study of

LIANG Yumei, LI Xianghong, LU Youyong, LV Yali, ZHONG Mei, PU Xiaolu, LI Wenmei

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 87-94 doi: 10.1007/s11684-008-0016-z

Abstract: The biological behavior of gastrointestinal stromal tumors (GISTs) are highly variable. To investigate the biological behavior of GIST, we collected 83 cases of gastric and 62 cases of small intestinal GIST from the Department of Pathology of the Chinese PLA General Hospital. The parameters include age, primary tumor location, tumor diameter, mitotic index, tumor necrosis, risk assessment, clinical stage and the exon 11 mutation. All these were analyzed in 105 cases along with the follow-up data and tested by log rank and COX hazard proportional model. We find that the average age of gastric GIST was 55.4 years. Of the 62 cases that were followed up, 17 cases had metastasis or recurrence and the 5-year survival rate was (66.51 ± 17.06)%. For the small intestinal GIST, the average age was 50.6 years and 43 cases were followed up. Of these, 22 cases had metastasis or recurrence and the 5-year survival rate was (61.76 ± 18.30)%. Small intestinal GIST was more frequently associated with metastasis and tumor relapse than gastric GIST ( = 6.131, = 0.013). For gastric GIST, patients younger than 50 years ( = 0.046), the advanced clinical stage ( = 0.0001), the large tumor diameter ( = 0.0001), a high mitotic index ( = 0.0001), necrosis ( = 0.0001) and a high risk grade ( = 0.004) were all correlated with a lower survival rate. The COX hazard proportional model revealed that advanced clinical stage ( = 0.001), large tumor size ( = 0.001), a high mitotic index ( = 0.002) and the high risk grade ( = 0.018) indicated a poorer prognosis in gastric GIST. For small intestinal GIST, necrosis ( = 0.036) and advanced clinical stage ( = 0.010) were associated with lower survival rates and the clinical stage was shown to be an independent prognostic indicator. A total of 25 cases harbored mutations in exon 11. The frequency of mutation was 32% and 22.5% for gastric and small intestinal GIST, respectively. In gastric GIST, the mutated was predominant in patients older than 50 years of age. But in the small intestinal GIST, the mutated was predominant in the age group of 40–49 years. In conclusion, for gastric GIST, clinical stage, tumor size, mitotic index, and risk grade are the prognostic indicators. For small intestinal GIST, necrosis and clinical stage are the prognostic indicators. Small intestinal GIST are more aggressive than gastric GIST. The occurrence of mutation may correlate with the age of patients.
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Change and significance of T-cell subsets and TNF-α in patients with advanced malignant obstructive jaundice

ZHU Lidong, CHEN Xiaoping

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 364-368 doi: 10.1007/s11684-007-0070-y

Abstract: The aim of this article was to study the influence of immunity function of advanced malignant obstructive jaundice (MOJ) treated by percutaneous transhepatic biliary external and internal drainage. Ninety-six cases of MOJ were divided into two groups according to the different ways of biliary drainage. Fifty-two external drainage tubes were placed in 41 cases of percutaneous transhepatic biliary external drainage group and 66 metal stents were placed in 55 cases of percutaneous transhepatic biliary internal drainage group. Liver function, serum TNF- and cellular function were examined one day before operation and one week after operation and liver function was re-examined two weeks after operation, in order to observe the change and analyze the asso ciation among them and compare with the control group. All patients conditions were improved after operation. In the percutaneous transhepatic biliary external and internal drainage groups, the total level of bilirubin decreased from (343.54±105.56) μ mol/L and (321.19±110.50) μ mol/L to (290.56±103.46) μ mol/L and (283.72±104.95) μ mol/L after operation respectively, which were significantly lower than pre-operation (<0.05), but there was no significant difference between the two groups (>0.05). Serum alanine aminotransferase (ALT) of all patients one week after operation was significantly lower than that before operation. TNF- in percutaneous transhepatic biliary external and internal groups decreased from (108.58±19.95) pg/mL, (109.98±16.24) pg/mL of pre-operation to (104.32±19.59) pg/mL, (83.92±13.43) pg/mL of post-operation respectively, there was notable improvement (<0.01) in internal drainage group after operation. Patients serum CD4, CD3 and CD4/CD8 were notably increased, but CD8 was notably decreased (<0.05). There was no difference in external drainage group (>0.05). There was a significant difference between the two groups. Serum TNF- and ALT had positive correlation. Percutaneous transhepatic biliary internal or external drainage was an effective and important method to treat MOJ. Patients immune function was weak when they suffered MOJ, but body s cellular immune function can be notably improved after internal biliary drainage.
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Insult of gastroesophageal reflux on airway: clinical significance of pharyngeal nozzle

Zhonggao Wang,Zhiwei Hu,Jimin Wu,Feng Ji,Hongtao Wang,Yungang Lai,Xiang Gao,Yachan Ning,Chengchao Zhang,Zhitong Li,Weitao Liang,Jianjun Liu

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 117-122 doi: 10.1007/s11684-014-0343-1

Abstract:

At the very time of global paying the highest attention to the worst insults of smoking as well as haze on the airway, everybody knows both are exogenous and noticeable. However, people mostly, including many medical personnel, do not know how badly the gastroesophageal reflux (GER) insults on our own airway. Symptoms of GER are commonly seen as heartburn and regurgitation, which can be mostly tolerated. However, when the up going gastric content reversely passes the esophagus and then the distal pharynx, where it appears a beak like stricture, serving as a nozzle, so as to produce numerous micro-particles and reach the oro-nasal cavity and also the airway causing allergic rhinitis and asthmatic attacks, even pulmonary parenchyma lesions. It will reduce life quality or even jeopardize life. The point that the endogenous insult appears in the respiratory system, but originates from the digestive tract is not well known and often undiagnosed and not correctly treated. The GER induced airway challenge is a treatable and preventive entity, as soon as a diagnosis is made, a good relief could be expected by means of life style adjustment, medicine, or fixation of the patulous cardia through radiofrequency or fundoplication. The author Dr. Zhonggao Wang had suffered it for long and symptoms disappeared for 8 years after anti-reflux surgery. Here is a presentation of Dr. Zhonggao Wang and his team’s work and would call attention to the public so as to recognize this relatively unknown entity — a treatable condition occurring from human itself, but not from outside surroundings as smoking or haze does.

Keywords： gastroesophageal reflux     airway     pharyngeal nozzle     micro-aspiration     asthma    

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Scientific significance of ancient maps of Yellow River and Grand Canal for water conservancy in China

Xiaocong LI,

Frontiers of Structural and Civil Engineering 2009, Volume 3, Issue 4,   Pages 445-454 doi: 10.1007/s11709-009-0063-9

Abstract: Based on the study of ancient maps preserved in China and abroad, the systematic nature and practical meaning of the maps of the Yellow River and Grand Canal is demonstrated. It is pointed out that the ancient maps not only record the spatial information of the established water conservancy engineering for river harnessing but also the management systems of the rivers in history. Besides, the maps provide abundant information on nature, humanity, and geography and possess high value in academic research and art appreciation.

Keywords： information     management     established     appreciation     practical    

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Clinical significance of human papilloma virus infection in the cervical lesions

Shuang LI, Yu-Han MENG, Hu TING, Jian SHEN, Ding MA

Frontiers of Medicine 2010, Volume 4, Issue 3,   Pages 264-270 doi: 10.1007/s11684-010-0094-6

Abstract: Cervical lesions have been regarded as the common and frequently occurring diseases in China. Recently, the morbidity and youth tendency of cervical cancer have gradually increased. Cervical cancer, related with human papilloma virus (HPV) infection, has been one of the severest diseases threatening health and life of women, and is an infectious disease. The universality of HPV infection in the reproductive tract should not be ignored. The well-known risk factors of HPV infection in cervical lesions consist of high-risk sexual behaviors, immunosuppression, age, contraceptive methods, the concurrent infection of other sexually transmitted diseases, etc. The variation of cervical lesions induced by HPV infection is involved in the continuous pathological process, including the subclinical, latent, and persistent infection of high risk (HR)-HPV, chronic cervicitis with abnormal results of cytological examination, cervical intraepithelial neoplasia (CIN), and cervical cancer. The outcome of patients with HPV infection is influenced by many factors, such as HPV subtype dominance, persistent HPV infection, HPV loading dose, and multiple HPV infection. Controlling HR-HPV persistent infection should be an important strategy for reducing cervical lesions.

Keywords： cervical lesion     high risk-human papilloma virus     persistent infection     loading dose     cervical intraepithelial neoplasia     cervical cancer    

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Increasing significance of advanced physical/chemical processes in the development and application of

RULKENS Wim

Frontiers of Environmental Science & Engineering 2008, Volume 2, Issue 4,   Pages 385-396 doi: 10.1007/s11783-008-0073-1

Abstract: microbiological treatment methods are, only to a limited part, able to satisfy these needs, the role and significance

Keywords： control     beneficial     valuable     scarcity     Development    

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Significance of using isolated footing technique for residential construction on expansive soils

Harry FAR,Deacon FLINT

Frontiers of Structural and Civil Engineering 2017, Volume 11, Issue 1,   Pages 123-129 doi: 10.1007/s11709-016-0372-8

Abstract: Expansive soils cause problems with the founding of lightly loaded structures in many parts of the world. Foundation design for expansive soils is one of the most discussed and problematic issues in Australia as expansive soils were responsible for billions of dollars’ worth of damage to man-made structures such as buildings and roads. Several studies and reports indicate that one of the most common and least recognized problems causing severe structural damage to houses lies in expansive soils. In this study, a critical review has been carried out on the current Australian standards for building on expansive soils and they are compared with some techniques that are not included in the current Australian standards for residential slabs and footings. Based on the results of this review, the most effective and economical method has been proposed for construction of footings on all site classifications without restriction to 75mm of characteristic movement. In addition, it has become apparent that as design procedures for footings resting on sites with extreme characteristic movements are not included in the current Australian standards, there is a strong need for well-developed and simplified standard design procedures for characteristic soil movement of greater than 75mm to be included into the Australian Standards.

Keywords： expansive soils     residential slabs     isolated footings     Australian Standards    

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Role of the forkhead transcription factor FOXO-FOXM1 axis in cancer and drug resistance

Fung Zhao, Eric W.-F. Lam

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 376-380 doi: 10.1007/s11684-012-0228-0

Abstract: Recent research shows that the forkhead transcription factor FOXM1 is a direct transcriptional target

Keywords： FOXO3a     FOXM1     transcription factor     cancer     drug resistance     tumorigenesis    

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Clinical significance of para-aortic lymph node dissection and prognosis in ovarian cancer

Xianxian Li, Hui Xing, Lin Li, Yanli Huang, Min Zhou, Qiong Liu, Xiaomin Qin, Min He

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 96-100 doi: 10.1007/s11684-014-0316-4

Abstract: Cox model analysis of single factor suggested that lymph node status affected the survival rate (P<0.01), which was the death risk factor.

Keywords： ovarian cancer     para-aortic lymph node     pelvic lymph node    

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Reconsideration of endometriosis and its clinical significance

Lang Jinghe

Strategic Study of CAE 2009, Volume 11, Issue 10,   Pages 137-142

Abstract:

Endometriosis (EM) is one of the most common diseases which severely affect the health and reproductive function for women of childbearing age. Though the basic and clinical research in past decades, we have formed our unique and systemic opinion about the etiology of EM. The abnormal endometrial tissue in EM patients flows backward to abdominal and pelvic cavity, completes three-step procedure of attachment- aggression-angiogenesis, and ultimately develops into EM. In all variable influencing factors, including immune, inflammation or local micro-enviroment, the character of eutopic endometrium determines the fate of the backward-flowing endometrial tissue, live or die; for women, being ill or not. By further deeply exploring, the stem cell or its micro-enviroment in eutopic endometrium might play the key role. Besides, EM is considered as a tumor-like disorder. Our series of conceptions about EM pathogenesis could be summarized as "3A"  model, "eutopic endometrial determinant"  theory, and "stem cell origination"  hypothesis. All in all, the study about development mechanism of EM ultimately will help to find out the more efficient and sensitive method for diagnosis, and exploit much effective measure of treatment as well.

Keywords： Endometriosis     pathogenesis     diagnosis     treatment    

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Effect of oxytocin on gastric ischemia-reperfusion injury in rats

ZHANG Wenwen, ZHANG Jianfu, ZHANG Yongmei, XU Ming

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 433-437 doi: 10.1007/s11684-007-0085-4

Abstract: of the OT group were (102.45±48.00) μL, 2.65±0.40 ( = 6) res pectively; differences had statistical significance

Keywords： control     significant difference     surgical     statistical significance     Sprague-Dawley    

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LSSVM-based approach for refining soil failure criteria and calculating safety factor of slopes

Shiguo XIAO; Shaohong LI

Frontiers of Structural and Civil Engineering 2022, Volume 16, Issue 7,   Pages 871-881 doi: 10.1007/s11709-022-0863-8

Abstract: failure criteria of practical soil mass are very complex, and have significant influence on the safety factorto determine the failure criterion, the limit equilibrium method can be used to calculate the safety factorAnalysis of results of the safety factor of two three-dimensional homogeneous slopes shows that the maximum

Keywords： slope stability     safety factor     failure criterion     least square support vector machine    

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lncR-GAS5 upregulates the splicing factor to impair endothelial autophagy, leading to atherogenesis

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 317-329 doi: 10.1007/s11684-022-0931-4

Abstract: Moreover, serine/arginine-rich splicing factor 10 (SRSF10) knockdown increased the LC3II/LC3IMechanistically, lncR-GAS5 regulated the downstream splicing factor SRSF10 to impair autophagy

Keywords： lncR-GAS5     miR-193-5p     splicing factor SRSF10     autophagy     atherogenesis    

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Title Author Date Type Operation

Environmental pollution and DNA methylation: carcinogenesis, clinical significance, and practical applications

Yi Cao

Journal Article

Structural dimension optimization and mechanical response analysis of fabricated honeycomb plastic pavement slab

Zixuan CHEN; Tao LIU; Xiao MA; Hanyu TANG; Jianyou HUANG; Jianzhong PEI

Journal Article

Prognostic significance of clinicopathologic parameters in gastrointestinal stromal tumors: a study of

LIANG Yumei, LI Xianghong, LU Youyong, LV Yali, ZHONG Mei, PU Xiaolu, LI Wenmei

Journal Article

Change and significance of T-cell subsets and TNF-α in patients with advanced malignant obstructive jaundice

ZHU Lidong, CHEN Xiaoping

Journal Article

Insult of gastroesophageal reflux on airway: clinical significance of pharyngeal nozzle

Zhonggao Wang,Zhiwei Hu,Jimin Wu,Feng Ji,Hongtao Wang,Yungang Lai,Xiang Gao,Yachan Ning,Chengchao Zhang,Zhitong Li,Weitao Liang,Jianjun Liu

Journal Article

Scientific significance of ancient maps of Yellow River and Grand Canal for water conservancy in China

Xiaocong LI,

Journal Article

Clinical significance of human papilloma virus infection in the cervical lesions

Shuang LI, Yu-Han MENG, Hu TING, Jian SHEN, Ding MA

Journal Article

Increasing significance of advanced physical/chemical processes in the development and application of

RULKENS Wim

Journal Article

Significance of using isolated footing technique for residential construction on expansive soils

Harry FAR,Deacon FLINT

Journal Article

Role of the forkhead transcription factor FOXO-FOXM1 axis in cancer and drug resistance

Fung Zhao, Eric W.-F. Lam

Journal Article

Clinical significance of para-aortic lymph node dissection and prognosis in ovarian cancer

Xianxian Li, Hui Xing, Lin Li, Yanli Huang, Min Zhou, Qiong Liu, Xiaomin Qin, Min He

Journal Article

Reconsideration of endometriosis and its clinical significance

Lang Jinghe

Journal Article

Effect of oxytocin on gastric ischemia-reperfusion injury in rats

ZHANG Wenwen, ZHANG Jianfu, ZHANG Yongmei, XU Ming

Journal Article

LSSVM-based approach for refining soil failure criteria and calculating safety factor of slopes

Shiguo XIAO; Shaohong LI

Journal Article

lncR-GAS5 upregulates the splicing factor to impair endothelial autophagy, leading to atherogenesis

Journal Article